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15 تشرين الأول (أكتوبر) 2016 قبل ظهور أدوية الستاتين، العلاجات والطرق أثبتت فاعلية أقل لكنها كانت مهمة في ذلك الوقت للتقليل حيث أن الكوليسترول هو بادرة في بناء حمض الصفراء ، حين يفقد الجسم المزيد من أحماض الصفراء الستاتين تعد آمنة على المرضى .

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